Issue 95, 2019
From the journal:

Chemical Communications

Smart engineering of a dual-DNA machine with a high signal-to-noise ratio for one-pot robust and sensitive miRNA signaling†

Panzhu Qin,a   Li Yao,ab   Jianguo Xu, ORCID logo *a   Guodong Liu ORCID logo bc  and  Wei Chen ORCID logo *ac  

* Corresponding authors

a Engineering Research Center of Bioprocess, MOE, School of Food and Biological Engineering, Hefei University of Technology, Hefei, China
E-mail: jgxu0816@163.com, chenweishnu@163.com

b Department of Chemistry and Biochemistry, North Dakota State University, Fargo, North Dakota, USA

c Research Center for Biomedical and Health Science, School of Life and Health, Anhui Science & Technology University, Fengyang, China

Abstract

A target triggered dual-DNA machine, consisting of one rolling circle amplification (RCA)-based circular DNA machine (RCA-CDM) and one cyclical strand displacement amplification (CSDA)-based bidirectional DNA machine (CSDA-BDM), was developed for robust miRNA determination.

Graphical abstract: Smart engineering of a dual-DNA machine with a high signal-to-noise ratio for one-pot robust and sensitive miRNA signaling

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Article information

DOI
https://doi.org/10.1039/C9CC07442B
Article type
Communication
Submitted
22 Sep 2019
Accepted
03 Nov 2019
First published
04 Nov 2019

Chem. Commun., 2019,55, 14367-14370

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Smart engineering of a dual-DNA machine with a high signal-to-noise ratio for one-pot robust and sensitive miRNA signaling

P. Qin, L. Yao, J. Xu, G. Liu and W. Chen, Chem. Commun., 2019, 55, 14367 DOI: 10.1039/C9CC07442B

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