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Polymyxin derivatives as broad-spectrum antibiotic agents

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Abstract

We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model.

Graphical abstract: Polymyxin derivatives as broad-spectrum antibiotic agents

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Publication details

The article was received on 04 Sep 2019, accepted on 02 Oct 2019 and first published on 02 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06908A
Chem. Commun., 2019, Advance Article

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    Polymyxin derivatives as broad-spectrum antibiotic agents

    M. Su, M. Wang, Y. Hong, A. Nimmagadda, N. Shen, Y. Shi, R. Gao, E. Zhang, C. Cao and J. Cai, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06908A

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