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Development of 4-oxime-1,8-naphthalimide as a bioorthogonal turn-on probe for fluorogenic protein labeling

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Abstract

4-Oxime-1,8-naphthalimide was reported as a novel bioorthogonal turn-on probe based on 1,3-dipolar cycloaddition reactions between in situ generated nitrile oxide and alkenes/alkynes. The resulting isoxazole products displayed dramatically strong fluorescence enhancement upon photoirradiation through isoxazole–oxazole photoisomerization. This new methodology was successfully applied for in situ fluorogenic protein labeling.

Graphical abstract: Development of 4-oxime-1,8-naphthalimide as a bioorthogonal turn-on probe for fluorogenic protein labeling

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Publication details

The article was received on 31 Aug 2019, accepted on 02 Oct 2019 and first published on 03 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06769H
Chem. Commun., 2019, Advance Article

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    Development of 4-oxime-1,8-naphthalimide as a bioorthogonal turn-on probe for fluorogenic protein labeling

    Y. Tian, X. Li and D. Yin, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06769H

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