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An aminophosphonate ester ligand-containing platinum(ii) complex induces potent immunogenic cell death in vitro and elicits effective anti-tumour immune responses in vivo

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Abstract

A platinum(II) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) in association with potent ER stress and reactive oxygen species generation, followed by the activation of damage-associated molecular pattern signals and immune responses. Importantly, the Pt complex exhibits potent anti-tumour activities in two independent mouse models via an immunogenic cell death pathway.

Graphical abstract: An aminophosphonate ester ligand-containing platinum(ii) complex induces potent immunogenic cell death in vitro and elicits effective anti-tumour immune responses in vivo

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Publication details

The article was received on 23 Aug 2019, accepted on 23 Sep 2019 and first published on 23 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC06563F
Chem. Commun., 2019, Advance Article

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    An aminophosphonate ester ligand-containing platinum(II) complex induces potent immunogenic cell death in vitro and elicits effective anti-tumour immune responses in vivo

    K. Huang, F. Wang, H. Feng, H. Luo, Y. Long, T. Zou, A. S. C. Chan, R. Liu, H. Zou, Z. Chen, Y. Liu, Y. Liu and H. Liang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06563F

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