Visible light-driven cross-coupling reactions of alkyl halides with phenylacetylene derivatives for C(sp3)–C(sp) bond formation catalyzed by a B12 complex

Abstract

Visible light-driven cross-coupling reactions of alkyl halides with phenylacetylene and its derivatives catalyzed by the cobalamin derivative (B₁₂) with the [Ir(dtbbpy)(ppy)₂]PF₆ photocatalyst at room temperature are reported. The robust B₁₂ catalyst and Ir photocatalyst provided high turnover numbers of over 33 000 for the reactions.