Issue 90, 2019
From the journal:

Chemical Communications

A cyanine-derivative photosensitizer with enhanced photostability for mitochondria-targeted photodynamic therapy†

Xuan Zhao,‡a   Yanjun Yang,‡bc   Yan Yu,c   Siming Guo,a   Wenxing Wang ORCID logo *c  and  Sumin Zhu*a  

* Corresponding authors

a Digestive Medicine Center, The second affiliated Hospital of Xuzhou Medical University, Xu Zhou 221000, China
E-mail: njzhusumin@163.com

b College of Chemistry, Shandong Normal University, Jinan 250014, China

c Department of Light Sources and Illuminating Engineering, and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China
E-mail: wangwenxing@fudan.edu.cn

Abstract

A cyanine-derivative photosensitizer, CYBF2, was synthesized for photodynamic therapy of cancer. The photosensitizer can be activated by red-light with enhanced photostability compared to traditional cyanine photosensitizers. CYBF2 was able to generate singlet oxygen inside the cell mitochondria, which efficiently resulted in apoptosis of cancer cells.

Graphical abstract: A cyanine-derivative photosensitizer with enhanced photostability for mitochondria-targeted photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C9CC06157F
Article type
Communication
Submitted
08 Aug 2019
Accepted
11 Oct 2019
First published
24 Oct 2019

Chem. Commun., 2019,55, 13542-13545

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A cyanine-derivative photosensitizer with enhanced photostability for mitochondria-targeted photodynamic therapy

X. Zhao, Y. Yang, Y. Yu, S. Guo, W. Wang and S. Zhu, Chem. Commun., 2019, 55, 13542 DOI: 10.1039/C9CC06157F

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