Jump to main content
Jump to site search

Issue 90, 2019
Previous Article Next Article

Unorthodox crystalline drug salts via the reaction of amine-containing drugs with CO2

Author affiliations

Abstract

Drugs containing amine groups react with CO2 to form crystalline ammonium carbamates or carbamic acids. In this approach, both the cation and anion of the salt, or the neutral CO2 adduct, are derived from the parent drug, generating new crystalline versions in a ‘masked’ or prodrug form. It is proposed that this approach may serve as a valuable new tool in engineering the physical properties of drugs for formulation purposes.

Graphical abstract: Unorthodox crystalline drug salts via the reaction of amine-containing drugs with CO2

Back to tab navigation

Supplementary files

Article information


Submitted
20 Aug 2019
Accepted
17 Oct 2019
First published
17 Oct 2019

Chem. Commun., 2019,55, 13546-13549
Article type
Communication

Unorthodox crystalline drug salts via the reaction of amine-containing drugs with CO2

M. Soltani, B. L. Mash, J. Henseler, S. Badri, M. Zeller, E. A. Salter, A. Wierzbicki, A. C. Stenson and J. H. Davis, Chem. Commun., 2019, 55, 13546
DOI: 10.1039/C9CC06429J

Social activity

Search articles by author

Spotlight

Advertisements