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Probing protein-protein and protein-substrate interactions in the dynamic membrane-associated ternary complex of Cytochromes P450, b5, and Reductase

Abstract

Cytochrome P450 (cytP450) interacts with two redox partners, cytP450 reductase and cytochrome-b5, to metabolize substrates. Using NMR, we reveal changes in the dynamic interplay when all three proteins are incorporated into lipid nanodiscs in the absence and presence of substrates.

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Publication details

The article was received on 29 Jul 2019, accepted on 24 Sep 2019 and first published on 02 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC05904K
Chem. Commun., 2019, Accepted Manuscript

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    Probing protein-protein and protein-substrate interactions in the dynamic membrane-associated ternary complex of Cytochromes P450, b5, and Reductase

    K. A. Gentry, G. M. Anantharamaiah and A. Ramamoorthy, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC05904K

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