Issue 89, 2019
From the journal:

Chemical Communications

Type III-C rotaxane dendrimers: synthesis, dual size modulation and in vivo evaluation†

Chak-Shing Kwan,‡a   Tao Wang,‡a   Min Li,b   Albert S. C. Chan,c   Zongwei Cai ORCID logo *a  and  Ken Cham-Fai Leung ORCID logo *a  

* Corresponding authors

a Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, P. R. China
E-mail: cfleung@hkbu.edu.hk, zwcai@hkbu.edu.hk

b School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, P. R. China

c School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, P. R. China

Abstract

Type III-C rotaxane dendrimers were synthesized by a divergent approach. Dual shuttling behavior and size modulation were observed from non-methylated/methylated rotaxane dendrimers under the same external stimuli. The biological distribution of dendrimers in C57BL/6J mice determined by MALDI-TOF-MS shows predominant accumulation in the spleen and liver. Drug encapsulations with chlorambucil and lithocholic acid were demonstrated.

Graphical abstract: Type III-C rotaxane dendrimers: synthesis, dual size modulation and in vivo evaluation

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Article information

DOI
https://doi.org/10.1039/C9CC06200A
Article type
Communication
Submitted
13 Aug 2019
Accepted
14 Oct 2019
First published
14 Oct 2019

Chem. Commun., 2019,55, 13426-13429

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Type III-C rotaxane dendrimers: synthesis, dual size modulation and in vivo evaluation

C. Kwan, T. Wang, M. Li, A. S. C. Chan, Z. Cai and K. C. Leung, Chem. Commun., 2019, 55, 13426 DOI: 10.1039/C9CC06200A

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