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First access to a mycolic acid-based bioorthogonal reporter for the study of the mycomembrane and mycoloyltransferases in Corynebacteria

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Abstract

In this study, we report the first synthesis of an alkyne-based trehalose monomycolate probe containing a β-hydroxylated fatty acid and an α-branched chain similar to those of the natural mycolic acid. We demonstrate its utility for the labeling of the mycomembrane of Corynebacteria as well as for the study of mycoloyltransferases.

Graphical abstract: First access to a mycolic acid-based bioorthogonal reporter for the study of the mycomembrane and mycoloyltransferases in Corynebacteria

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Publication details

The article was received on 24 Jul 2019, accepted on 26 Sep 2019 and first published on 27 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC05754D
Chem. Commun., 2019, Advance Article

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    First access to a mycolic acid-based bioorthogonal reporter for the study of the mycomembrane and mycoloyltransferases in Corynebacteria

    E. Lesur, A. Baron, C. Dietrich, M. Buchotte, G. Doisneau, D. Urban, J. Beau, N. Bayan, B. Vauzeilles, D. Guianvarc’h and Y. Bourdreux, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC05754D

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