A photo-stable and reversible pH-responsive nano-agent based on the NIR phenazine dye for photoacoustic imaging-guided photothermal therapy

Yongchao Yan; Hao Fu; Jian Wang; Chuanrong Chen; Qi Wang; Yourong Duan; Jianli Hua

doi:10.1039/C9CC05624F

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A photo-stable and reversible pH-responsive nano-agent based on the NIR phenazine dye for photoacoustic imaging-guided photothermal therapy†

Yongchao Yan,‡^a Hao Fu,‡^b Jian Wang,^a Chuanrong Chen,^b Qi Wang,

^a Yourong Duan

*^b and Jianli Hua

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China
E-mail: jlhua@ecust.edu.cn

^b State Key Laboratory of Oncogenes and Related Genes, Reiji Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, 25 Xietu Road, Shanghai 200032, P. R. China
E-mail: yrduan@shsci.org

Abstract

Different from traditional “always on” photothermal therapy (PTT) agents, tumor microenvironment responsive agents showed more tumor specificity and lower photo-toxicity to normal tissues. Herein, a photo-stable and reversible pH responsive phenazine dye (PIOH) was synthesized and assembled with liposomes forming nanoparticles (PIOH-NPs), which exhibited a strong NIR absorption in a weak acid environment and were successfully utilized for photoacoustic (PA) imaging-guided photothermal therapy in mice.

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DOI: https://doi.org/10.1039/C9CC05624F
Article type: Communication
Submitted: 20 Jul 2019
Accepted: 14 Aug 2019
First published: 14 Aug 2019

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Chem. Commun., 2019,55, 10940-10943

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A photo-stable and reversible pH-responsive nano-agent based on the NIR phenazine dye for photoacoustic imaging-guided photothermal therapy

Y. Yan, H. Fu, J. Wang, C. Chen, Q. Wang, Y. Duan and J. Hua, Chem. Commun., 2019, 55, 10940 DOI: 10.1039/C9CC05624F

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Chemical Communications

A photo-stable and reversible pH-responsive nano-agent based on the NIR phenazine dye for photoacoustic imaging-guided photothermal therapy†

Abstract

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A photo-stable and reversible pH-responsive nano-agent based on the NIR phenazine dye for photoacoustic imaging-guided photothermal therapy

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