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Issue 68, 2019
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Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic E. coli

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Abstract

We developed a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains. Mannose-grafted cellulose proved efficient to selectively bind FimH lectin and discriminate pathogenic E. coli strains from non-pathogenic ones. These modified papers are valuable tools for diagnosing infections promoted by E. coli, such as cystitis or inflammatory bowel diseases, and the concept may be applicable to other life-threatening pathogens.

Graphical abstract: Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic E. coli

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Article information


Submitted
18 Jul 2019
Accepted
02 Aug 2019
First published
02 Aug 2019

Chem. Commun., 2019,55, 10158-10161
Article type
Communication

Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic E. coli

M. Cauwel, A. Sivignon, C. Bridot, M. C. Nongbe, D. Deniaud, B. Roubinet, L. Landemarre, F. Felpin, J. Bouckaert, N. Barnich and S. G. Gouin, Chem. Commun., 2019, 55, 10158
DOI: 10.1039/C9CC05545B

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