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Issue 68, 2019
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Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic E. coli

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Abstract

We developed a chemical method to covalently functionalize cellulose nanofibers and cellulose paper with mannoside ligands displaying a strong affinity for the FimH adhesin from pathogenic E. coli strains. Mannose-grafted cellulose proved efficient to selectively bind FimH lectin and discriminate pathogenic E. coli strains from non-pathogenic ones. These modified papers are valuable tools for diagnosing infections promoted by E. coli, such as cystitis or inflammatory bowel diseases, and the concept may be applicable to other life-threatening pathogens.

Graphical abstract: Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic E. coli

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Publication details

The article was received on 18 Jul 2019, accepted on 02 Aug 2019 and first published on 02 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC05545B
Chem. Commun., 2019,55, 10158-10161

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    Heptylmannose-functionalized cellulose for the binding and specific detection of pathogenic E. coli

    M. Cauwel, A. Sivignon, C. Bridot, M. C. Nongbe, D. Deniaud, B. Roubinet, L. Landemarre, F. Felpin, J. Bouckaert, N. Barnich and S. G. Gouin, Chem. Commun., 2019, 55, 10158
    DOI: 10.1039/C9CC05545B

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