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Issue 76, 2019
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Rhodium-catalyzed arylative cyclization of alkynyl malonates by 1,4-rhodium(i) migration

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Abstract

The synthesis of functionalized 1-tetralones by the rhodium(I)-catalyzed reaction of alkynyl malonates with arylboronic acids is described. These arylative cyclizations proceed via an alkenyl-to-aryl 1,4-Rh(I) migration as a key step. Preliminary results of an enantioselective variant of these reactions are also presented.

Graphical abstract: Rhodium-catalyzed arylative cyclization of alkynyl malonates by 1,4-rhodium(i) migration

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Article information


Submitted
07 Jul 2019
Accepted
19 Aug 2019
First published
26 Aug 2019

Chem. Commun., 2019,55, 11366-11369
Article type
Communication

Rhodium-catalyzed arylative cyclization of alkynyl malonates by 1,4-rhodium(I) migration

L. O’Brien, S. N. Karad, W. Lewis and H. W. Lam, Chem. Commun., 2019, 55, 11366
DOI: 10.1039/C9CC05205D

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