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Issue 59, 2019
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Cascade alkylation and deuteration with aryl iodides via Pd/norbornene catalysis: an efficient method for the synthesis of congested deuterium-labeled arenes

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Abstract

An efficient approach for synthesizing congested deuterium-labeled arenes via cascade alkylation and deuteration with aryl iodides has been disclosed. We found that the adoption of sodium formate-d as a deuterium source is the key for achieving high deuterium incorporation >98%.

Graphical abstract: Cascade alkylation and deuteration with aryl iodides via Pd/norbornene catalysis: an efficient method for the synthesis of congested deuterium-labeled arenes

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Submitted
23 May 2019
Accepted
25 Jun 2019
First published
25 Jun 2019

Chem. Commun., 2019,55, 8567-8570
Article type
Communication

Cascade alkylation and deuteration with aryl iodides via Pd/norbornene catalysis: an efficient method for the synthesis of congested deuterium-labeled arenes

L. Guo, C. Xu, D. Wu, G. Hu, H. Zhang, K. Hong, S. Chen and X. Liu, Chem. Commun., 2019, 55, 8567
DOI: 10.1039/C9CC03988K

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