A BODIPY biosensor to detect and drive self-assembly of diphenylalanine

Li Quan; Jianhua Gu; Wenhai Lin; Yanchun Wei; Yuebin Lin; Lei Liu; Hongyan Ding; Changjiang Pan; Zhigang Xie; Tianfu Wu

doi:10.1039/C9CC03810H

A BODIPY biosensor to detect and drive self-assembly of diphenylalanine†

Li Quan,

*^a Jianhua Gu,^c Wenhai Lin,

^d Yanchun Wei,

^a Yuebin Lin,^a Lei Liu,^a Hongyan Ding,^a Changjiang Pan,^a Zhigang Xie

*^d and Tianfu Wu*^b

Author affiliations

* Corresponding authors

^a Department of Mechanical and Material Engineering, Huaiyin Institute of Technology, Huai’an 223003, Jiangsu Province, China
E-mail: quanxiaofei2018@gmail.com

^b Department of Biomedical Engineering, University of Houston, Houston, Texas 77204, USA
E-mail: twu13@central.uh.edu

^c Electron Microscopy Core, Houston Methodist Research Institute, Houston, TX 77030, USA

^d State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
E-mail: xiez@ciac.ac.cn

Abstract

Diphenylalanine (FF), as the smallest unit and core recognition motif of β-amyloid (Aβ), could self-assemble into nanofibers, which induces an early onset of Alzheimer's disease (AD). Green/near-infrared fluorescent BODIPY probes were designed and synthesized to detect FF-assembly, providing unique insights into the chemical and molecular mechanism of Aβ aggregation and drug development for AD.

Chemical Communications

A BODIPY biosensor to detect and drive self-assembly of diphenylalanine†

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A BODIPY biosensor to detect and drive self-assembly of diphenylalanine

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