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Issue 80, 2019
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Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity

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Abstract

Redox-modulating anticancer drugs allow the exploitation of altered redox biology observed in many cancer cells. We discovered dinuclear RhIII(Cp*) and IrIII(Cp*) complexes that have in vitro anticancer activity superior to cisplatin and the investigational drug IT-139, while being less toxic in haemolysis and in vivo zebrafish models. The mode of action appears to be related to DNA damage and ROS-mediated stress pathways.

Graphical abstract: Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity

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Article information


Submitted
17 May 2019
Accepted
29 Aug 2019
First published
30 Aug 2019

Chem. Commun., 2019,55, 12016-12019
Article type
Communication

Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity

S. Parveen, M. Hanif, E. Leung, K. K. H. Tong, A. Yang, J. Astin, G. H. De Zoysa, T. R. Steel, D. Goodman, S. Movassaghi, T. Söhnel, V. Sarojini, S. M. F. Jamieson and C. G. Hartinger, Chem. Commun., 2019, 55, 12016 DOI: 10.1039/C9CC03822A

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