Issue 46, 2019

Ring-opening cyclization of spirocyclopropanes with stabilized sulfonium ylides for the construction of a chromane skeleton

Abstract

Regioselective ring-opening cyclization of cyclohexane-1,3-dione-2-spirocyclopropanes with stabilized sulfonium ylides provided 2,3-trans-disubstituted 2,3,4,6,7,8-hexahydro-5H-1-benzopyran-5-ones in high yields without the formation of any isomers. The obtained product was readily converted into highly substituted chromane.

Graphical abstract: Ring-opening cyclization of spirocyclopropanes with stabilized sulfonium ylides for the construction of a chromane skeleton

Supplementary files

Article information

Article type
Communication
Submitted
18 Apr 2019
Accepted
13 May 2019
First published
14 May 2019

Chem. Commun., 2019,55, 6539-6542

Ring-opening cyclization of spirocyclopropanes with stabilized sulfonium ylides for the construction of a chromane skeleton

H. Nambu, Y. Onuki, N. Ono, K. Tsuge and T. Yakura, Chem. Commun., 2019, 55, 6539 DOI: 10.1039/C9CC03023A

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