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Issue 51, 2019
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Robust scalable synthesis of a bis-urea derivative forming thixotropic and cytocompatible supramolecular hydrogels

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Abstract

Synthetic hydrogels address a need for affordable, industrially scalable scaffolds for tissue engineering. Herein, a novel low molecular weight gelator is reported that forms self-healing supramolecular hydrogels. Its robust synthesis can be performed in a solvent-free manner using ball milling. Strikingly, encapsulated cells spread and proliferate without specific cell adhesion ligands in the nanofibrous material.

Graphical abstract: Robust scalable synthesis of a bis-urea derivative forming thixotropic and cytocompatible supramolecular hydrogels

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Article information


Submitted
15 Apr 2019
Accepted
27 May 2019
First published
06 Jun 2019

Chem. Commun., 2019,55, 7323-7326
Article type
Communication

Robust scalable synthesis of a bis-urea derivative forming thixotropic and cytocompatible supramolecular hydrogels

L. A. J. Rutgeerts, A. H. Soultan, R. Subramani, B. Toprakhisar, H. Ramon, M. C. Paderes, W. M. De Borggraeve and J. Patterson, Chem. Commun., 2019, 55, 7323
DOI: 10.1039/C9CC02927C

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