Issue 51, 2019

New β-carboline fluorophores with superior sensitivity and endoplasmic reticulum specificity for tracking ER changes

Abstract

Autofluorescing carboline-fluors were efficiently and rationally developed via a Pictet–Spengler involved one-pot multi-component reaction. The carboline-fluors demonstrate specific targeting towards the endoplasmic reticulum in living cells, and superior sensitivity to commercial ER-Trackers. Importantly, they were also successfully used to visualize changes in the ER during cell apoptosis and ER stress.

Graphical abstract: New β-carboline fluorophores with superior sensitivity and endoplasmic reticulum specificity for tracking ER changes

Supplementary files

Article information

Article type
Communication
Submitted
02 May 2019
Accepted
24 May 2019
First published
27 May 2019

Chem. Commun., 2019,55, 7327-7330

New β-carboline fluorophores with superior sensitivity and endoplasmic reticulum specificity for tracking ER changes

W. Chen, J. Shao, Y. Huang, E. Chen, M. Huang, F. Han, X. Liang and Y. Yu, Chem. Commun., 2019, 55, 7327 DOI: 10.1039/C9CC03370J

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