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Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions

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Abstract

Blending synthetic biology and synthetic chemistry represents a powerful approach to diversity complex molecules. To further enable this, compatible synthetic tools are needed. We report the first Buchwald Hartwig amination reactions with unprotected halotryptophans under aqueous conditions and demonstrate this methodology is applicable also to the modification of unprotected tripeptides and the natural product barettin.

Graphical abstract: Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions

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Publication details

The article was received on 02 Apr 2019, accepted on 10 Jun 2019 and first published on 08 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC02554E
Chem. Commun., 2019, Advance Article
  • Open access: Creative Commons BY license
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    Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions

    Y. J. G. Renault, R. Lynch, E. Marelli, S. V. Sharma, C. Pubill-Ulldemolins, J. A. Sharp, C. Cartmell, P. Cárdenas and R. J. M. Goss, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC02554E

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