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Issue 57, 2019
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Functionalisation of isoindolinones via a calcium catalysed Hosomi–Sakurai allylation

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Abstract

A rapid and functionally tolerant calcium catalysed Hosomi–Sakurai reaction has been realised. Employing 1 mol% calcium, allylated isoindolinones can be synthesised in high yields and the reaction is shown to be tolerant to a range of medicinally relevant functional groups including heterocycles. The synthetic utility of the reaction has been shown, and a plausible reaction mechanism is provided.

Graphical abstract: Functionalisation of isoindolinones via a calcium catalysed Hosomi–Sakurai allylation

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Supplementary files

Article information


Submitted
29 Mar 2019
Accepted
24 Jun 2019
First published
24 Jun 2019

This article is Open Access

Chem. Commun., 2019,55, 8317-8320
Article type
Communication

Functionalisation of isoindolinones via a calcium catalysed Hosomi–Sakurai allylation

A. J. Basson and M. G. McLaughlin, Chem. Commun., 2019, 55, 8317
DOI: 10.1039/C9CC02450F

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