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Programming a split G-quadruplex in a DNA nanocage and its microRNA imaging in live cells

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Abstract

A novel approach to program target-responsive devices by incorporating the split G4 motifs in a DNA nanocage has been developed. The rigid prism outcompetes the flexible one in reaction kinetics and signal/background ratios, which can be easily internalized by cells and successfully applied in microRNA imaging in live cells.

Graphical abstract: Programming a split G-quadruplex in a DNA nanocage and its microRNA imaging in live cells

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Publication details

The article was received on 14 Mar 2019, accepted on 01 Apr 2019 and first published on 01 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC02096A
Citation: Chem. Commun., 2019, Advance Article

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    Programming a split G-quadruplex in a DNA nanocage and its microRNA imaging in live cells

    Y. Yu, Y. Zhou, M. Zhu, M. Liu, H. Zhu, Y. Chen, G. Su, W. Chen and H. Peng, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC02096A

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