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Issue 35, 2019
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Simple alkanoyl acylating agents for reversible RNA functionalization and control

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Abstract

We describe the synthesis and RNA acylation activity of a series of minimalist azidoalkanoyl imidazole reagents, with the aim of functionalizing RNA at 2′-hydroxyl groups at stoichiometric to superstoichiometric levels. We find marked effects of small structural changes on their ability to acylate and be reductively removed, and identify reagents and methods that enable efficient RNA functionalization and control.

Graphical abstract: Simple alkanoyl acylating agents for reversible RNA functionalization and control

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Supplementary files

Article information


Submitted
26 Feb 2019
Accepted
03 Apr 2019
First published
03 Apr 2019

Chem. Commun., 2019,55, 5135-5138
Article type
Communication

Simple alkanoyl acylating agents for reversible RNA functionalization and control

H. S. Park, A. M. Kietrys and E. T. Kool, Chem. Commun., 2019, 55, 5135
DOI: 10.1039/C9CC01598A

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