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Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4

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Abstract

Biochemical and structural studies provide information on the mode of action of FGF401 as a selective, reversible covalent inhibitor of FGFR4. Kinase and proliferation assays reveal that FGF401 has the ability to overcome gatekeeper mutations in FGFR4.

Graphical abstract: Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4

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Publication details

The article was received on 13 Mar 2019, accepted on 23 Apr 2019 and first published on 26 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC02052G
Chem. Commun., 2019, Advance Article

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    Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4

    Z. Zhou, X. Chen, Y. Fu, Y. Zhang, S. Dai, J. Li, L. Chen, G. Xu, Z. Chen and Y. Chen, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC02052G

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