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Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis

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Abstract

A tunable chemoenzymatic strategy provides access to the entire class of magic spot nucleotides and modified analogues. The approach combines chemoselective bisphosphorylations using phosphoramidites with regioselective ribonuclease T2 cyclo-phosphate hydrolysis, leading to flexible and simple gram-scale operations.

Graphical abstract: Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis

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Publication details

The article was received on 28 Feb 2019, accepted on 08 Apr 2019 and first published on 08 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC01688K
Citation: Chem. Commun., 2019, Advance Article

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    Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis

    T. M. Haas, P. Ebensperger, V. B. Eisenbeis, C. Nopper, T. Dürr, N. Jork, N. Steck, C. Jessen-Trefzer and H. J. Jessen, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC01688K

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