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Precise ricin A-chain delivery by Golgi-targeting carbon dots

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Abstract

A precise ricin A-chain (RTA) delivery system was constructed by coupling RTA to carbon dots (CDs) with a distinctive capacity for Golgi targeting. The rational design shows efficient internalization and an exact pathway to the cytoplasm for RTA to exert its real toxic action since it could avoid lysosome degradation.

Graphical abstract: Precise ricin A-chain delivery by Golgi-targeting carbon dots

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Publication details

The article was received on 26 Feb 2019, accepted on 09 May 2019 and first published on 10 May 2019


Article type: Communication
DOI: 10.1039/C9CC01599J
Chem. Commun., 2019, Advance Article

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    Precise ricin A-chain delivery by Golgi-targeting carbon dots

    C. H. Li, R. S. Li, C. M. Li, C. Z. Huang and S. J. Zhen, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC01599J

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