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Issue 35, 2019
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5′-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger

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Abstract

The 5′-monophosphate group plays an important role in strand selection during gene silencing mediated by small-interfering RNA. We show that blocking of 5′ phosphorylation of the sense strand by introducing a 5′-morpholino modification improves antisense strand selection and RNAi activity. The 5′-morpholino modification of the antisense strand triggers complete loss of activity.

Graphical abstract: 5′-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger

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Publication details

The article was received on 02 Feb 2019, accepted on 11 Mar 2019 and first published on 01 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC00977A
Citation: Chem. Commun., 2019,55, 5139-5142

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    5′-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger

    P. Kumar, R. G. Parmar, C. R. Brown, J. L. S. Willoughby, D. J. Foster, I. R. Babu, S. Schofield, V. Jadhav, K. Charisse, J. K. Nair, K. G. Rajeev, M. A. Maier, M. Egli and M. Manoharan, Chem. Commun., 2019, 55, 5139
    DOI: 10.1039/C9CC00977A

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