Issue 57, 2019
From the journal:

Chemical Communications

Nuclear localization of dirhodium(ii) complexes in breast cancer cells by X-ray fluorescence microscopy†

Alejandra Enriquez Garcia,a   Barry Lai,b   Sesha Gopal Gopinathan,c   Hugh H. Harris, ORCID logo d   Carrie S. Shemankoc  and  Farideh Jalilehvand ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Calgary, Calgary, AB T2N 1N4, Canada
E-mail: faridehj@ucalgary.ca

b Advanced Photon Source, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA

c Department of Biological Sciences, University of Calgary, Calgary, AB T2N 1N4, Canada

d Department of Chemistry, The University of Adelaide, SA 5005, Australia

Abstract

The cellular distribution of three dirhodium(II) complexes with a paddlewheel structure was investigated using synchrotron-based X-ray fluorescence microscopy and cell viability studies. Complexes with vacant axial sites displayed cytotoxic activity and nuclear accumulation whereas complexes in which the axial positions were blocked showed little to no toxicity nor uptake.

Graphical abstract: Nuclear localization of dirhodium(ii) complexes in breast cancer cells by X-ray fluorescence microscopy

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Article information

DOI
https://doi.org/10.1039/C9CC00521H
Article type
Communication
Submitted
21 Jan 2019
Accepted
05 Jun 2019
First published
05 Jun 2019

Chem. Commun., 2019,55, 8223-8226

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Nuclear localization of dirhodium(II) complexes in breast cancer cells by X-ray fluorescence microscopy

A. Enriquez Garcia, B. Lai, S. G. Gopinathan, H. H. Harris, C. S. Shemanko and F. Jalilehvand, Chem. Commun., 2019, 55, 8223 DOI: 10.1039/C9CC00521H

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