Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties

Ana I. Carbajo-Gordillo; Julio Rodríguez-Lavado; José Luis Jiménez Blanco; Juan M. Benito; Christophe Di Giorgio; Itziar Vélaz; Concepción Tros de Ilarduya; Carmen Ortiz Mellet; José M. García Fernández

doi:10.1039/C9CC04489B

Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties†

Ana I. Carbajo-Gordillo,

‡^a Julio Rodríguez-Lavado,

‡^b José Luis Jiménez Blanco,

^b Juan M. Benito,

^a Christophe Di Giorgio,

^c Itziar Vélaz,

^d Concepción Tros de Ilarduya,

*^e Carmen Ortiz Mellet

*^b and José M. García Fernández

*^a

Author affiliations

* Corresponding authors

^a Instituto de Investigaciones Químicas (IIQ), CSIC – Universidad de Sevilla, Avda. Américo Vespucio 49, Isla de la Cartuja, 41092 Sevilla, Spain
E-mail: jogarcia@iiq.csic.es

^b Department of Organic Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, 41012 Seville, Spain
E-mail: mellet@us.es

^c Institut de Chimie Nice, UMR 7272, Université de Nice Sophia Antipolis, CNRS, 28, Avenue de Valrose, F-06108 Nice, France

^d Department of Chemistry, Faculty of Sciences, University of Navarra, Pamplona, Spain

^e Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, 31080 Pamplona, Spain
E-mail: ctros@unav.es

Abstract

An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery in vitro and in vivo.

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DOI: https://doi.org/10.1039/C9CC04489B
Article type: Communication
Submitted: 11 Jun 2019
Accepted: 18 Jun 2019
First published: 19 Jun 2019
This article is Open Access

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Chem. Commun., 2019,55, 8227-8230

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Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties

A. I. Carbajo-Gordillo, J. Rodríguez-Lavado, J. L. Jiménez Blanco, J. M. Benito, C. Di Giorgio, I. Vélaz, C. Tros de Ilarduya, C. Ortiz Mellet and J. M. García Fernández, Chem. Commun., 2019, 55, 8227 DOI: 10.1039/C9CC04489B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Communications

Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties†

Abstract

Supplementary files

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Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties

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