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A novel thermo-responsive multiblock architecture composed of a sequential peptide and an amino acid-derived vinyl polymer: toward protein-mimicking single-chain folding

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Abstract

A novel multiblock architecture composed of an alternating β-sheet forming oligopeptide and a thermo-responsive glycine-derived vinyl polymer was synthesized. The polymer exhibited lower critical solution temperature (LCST) behavior in water, unlike the behavior of a glycine-derived homopolymer, and formed nanoparticles through protein-mimicking folding driven by thermal cycle-induced β-sheet formation.

Graphical abstract: A novel thermo-responsive multiblock architecture composed of a sequential peptide and an amino acid-derived vinyl polymer: toward protein-mimicking single-chain folding

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Publication details

The article was received on 14 Nov 2018, accepted on 09 Jan 2019 and first published on 10 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC09051C
Citation: Chem. Commun., 2019, Advance Article
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    A novel thermo-responsive multiblock architecture composed of a sequential peptide and an amino acid-derived vinyl polymer: toward protein-mimicking single-chain folding

    S. Nishimura, N. Higashi and T. Koga, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC09051C

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