Issue 10, 2019
From the journal:

Chemical Communications

A ratiometric fluorescent probe of methionine sulfoxide reductase with an improved response rate and emission wavelength†

Liangwei Zhang, ORCID logo *ab   Shoujiao Peng, ORCID logo ac   Jinyu Sun,a   Ruijuan Liu,a   Shudi Liua  and  Jianguo Fang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
E-mail: fangjg@lzu.edu.cn

b Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
E-mail: liangweizhang@yic.ac.cn

c Department of Molecular Medicine, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA

Abstract

A ratiometric fluorescent probe of methionine sulfoxide reductase, Msr-Ratio, was disclosed for monitoring the enzyme activity in vitro and in live cells. The probe displayed favorable properties such as a nearly 400-fold fluorescence change, fast response rate (<30 min), large Stokes shift (120 nm), and green emission (550 nm).

Graphical abstract: A ratiometric fluorescent probe of methionine sulfoxide reductase with an improved response rate and emission wavelength

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Article information

DOI
https://doi.org/10.1039/C8CC08879A
Article type
Communication
Submitted
07 Nov 2018
Accepted
02 Jan 2019
First published
03 Jan 2019

Chem. Commun., 2019,55, 1502-1505

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A ratiometric fluorescent probe of methionine sulfoxide reductase with an improved response rate and emission wavelength

L. Zhang, S. Peng, J. Sun, R. Liu, S. Liu and J. Fang, Chem. Commun., 2019, 55, 1502 DOI: 10.1039/C8CC08879A

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