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Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs

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Abstract

Iron-containing metallic implants are shown herein to mediate hydrolysis of glycosidic linkages. Using glucuronide prodrugs for broad-spectrum fluoroquinolone antibacterial agents, we capitalize on this behaviour and perform localized synthesis of antimicrobials which affords a significant zone of inhibition of bacterial growth around the metallic material.

Graphical abstract: Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs

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Publication details

The article was received on 01 Nov 2018, accepted on 23 Nov 2018 and first published on 29 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08737G
Citation: Chem. Commun., 2019, Advance Article
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    Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs

    M. ter Meer, R. Dillion, S. M. Nielsen, R. Walther, R. L. Meyer, W. F. Daamen, L. P. van den Heuvel, J. A. van der Vliet, R. M. L. M. Lomme, Y. L. Hoogeveen, L. J. Schultze Kool, J. E. Schaffer and A. N. Zelikin, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC08737G

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