Issue 4, 2019
From the journal:

Chemical Communications

Efficient and stable radiolabeling of polycyclic aromatic hydrocarbon assemblies: in vivo imaging of diesel exhaust particulates in mice†

Chang Heon Lee,‡a   Ha Eun Shim,‡a   Lee Song,a   Hi Gyu Moon,b   Kyuhong Lee,b   Jung Eun Yang,c   Ha Yeon Song,a   Yong Jun Choi,d   Dae Seong Choia  and  Jongho Jeon ORCID logo *ae  

* Corresponding authors

a Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea
E-mail: jeonj@kaeri.re.kr

b Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeongeup 56212, Republic of Korea

c World Institute of Kimchi, Gwangju 61755, Republic of Korea

d School of Environmental Engineering, University of Seoul, Seoul 02504, Republic of Korea

e Radiation Biotechnology and Applied Radioisotope Science, University of Science and Technology, Daejeon 34113, Republic of Korea

Abstract

As a robust radioanalytical method for tracking carbonaceous particulates in vivo, polycyclic aromatic hydrocarbons from diesel exhaust were labeled with a radioactive-iodine-tagged pyrene analogue. Single-photon emission computed tomography and biodistribution studies showed high uptake and slow clearance of this matter in the respiratory system, which may underlie its severe toxicity.

Graphical abstract: Efficient and stable radiolabeling of polycyclic aromatic hydrocarbon assemblies: in vivo imaging of diesel exhaust particulates in mice

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Article information

DOI
https://doi.org/10.1039/C8CC08304E
Article type
Communication
Submitted
17 Oct 2018
Accepted
13 Nov 2018
First published
26 Nov 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2019,55, 447-450

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Efficient and stable radiolabeling of polycyclic aromatic hydrocarbon assemblies: in vivo imaging of diesel exhaust particulates in mice

C. H. Lee, H. E. Shim, L. Song, H. G. Moon, K. Lee, J. E. Yang, H. Y. Song, Y. J. Choi, D. S. Choi and J. Jeon, Chem. Commun., 2019, 55, 447 DOI: 10.1039/C8CC08304E

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