Jump to main content
Jump to site search

Issue 4, 2019
Previous Article Next Article

Improving NanoCluster Beacon performance by blocking the unlabeled NC probes

Author affiliations

Abstract

While NanoCluster Beacon (NCB) is a versatile molecular probe, it suffers from a low target-specific signal issue due to impurities. Here we show that adding a “blocker” strand to the reaction can effectively block the nonfunctional probes and enhance the target-specific signal by 14 fold at a 0.1 target/probe ratio.

Graphical abstract: Improving NanoCluster Beacon performance by blocking the unlabeled NC probes

Back to tab navigation

Supplementary files

Article information


Submitted
17 Oct 2018
Accepted
05 Dec 2018
First published
10 Dec 2018

Chem. Commun., 2019,55, 462-465
Article type
Communication
Author version available

Improving NanoCluster Beacon performance by blocking the unlabeled NC probes

Y. Chen, H. T. Vu, Y. Liu, Y. Chen, T. D. Nguyen, Y. Kuo, S. Hong, Y. Chen, S. Carnahan, J. T. Petty and H. Yeh, Chem. Commun., 2019, 55, 462
DOI: 10.1039/C8CC08291J

Social activity

Search articles by author

Spotlight

Advertisements