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Transition metal substituted sandwich-type polyoxometalates with a strong metal–C (imidazole) bond as anticancer agents

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Abstract

Two novel sandwich-type polyoxometalates {Na0.7M5.3(H2O)2(imi)2(Himi)(SbW9O33)2}6− (M = NiII (1), CoII (2), imi = imidazole) containing a strong M–Cimi bond were synthesized by a tetragonal cluster [Na2Sb8W36O132(H2O)4]22− {Sb8W36} precursor. Compound 1 was highly cytotoxic against gastric cancer cells by arresting the cell cycle in the S-phase and inducing cell apoptosis.

Graphical abstract: Transition metal substituted sandwich-type polyoxometalates with a strong metal–C (imidazole) bond as anticancer agents

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Publication details

The article was received on 02 Oct 2018, accepted on 20 Dec 2018 and first published on 21 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC07884J
Citation: Chem. Commun., 2019, Advance Article
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    Transition metal substituted sandwich-type polyoxometalates with a strong metal–C (imidazole) bond as anticancer agents

    H. Zhao, L. Tao, F. Zhang, Y. Zhang, Y. Liu, H. Xu, G. Diao and L. Ni, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC07884J

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