Hydrophilic and Degradable Polyester Based on L-aspartic Acid with Antibacterial Property for Potential Application in Hernia Repair
Polyester hernia patch has received extensive attention in mesh hernia repair. However, it is still a challenge to develop polyester-based implant with inherent antibacterial properties due to the lack of active functional groups. In this study, poly (butylene succinate-co-butylene aspartate) (PBSA) was constructed by introducing aspartic acid on polybutylene succinate (PBS) polyester chain (PBSA). Antimicrobial treatment was conducted by grafting of levofloxacin (Lv) on the surface of PBSA polymer (PBSA-g-Lv). In vitro antibacterial test result showed PBSA-g-Lv had sufficient local antimicrobiotic effects against the Staphylococcus aureus and Escherichia coli and no side effect on L929 cells was observed. Furthermore, there was almost no change in thermodynamic properties between PBS and PBSA, in vivo test demonstrated that this contact-active antibacterial PBSA-g-Lv nanofiber was a promising material to fulfill the dual functions of promoting tissue regeneration and preventing bacterial infection. The presented data confirmed that an antibiotic surface modification of PBSA polyesters was expected to be used as hernia repair materials.