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Polydopamine/puerarin nanoparticle-incorporated hybrid hydrogels for enhanced wound healing

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Abstract

Oxidative damage generated by various biochemical pathways can disrupt the oxidant/antioxidant balance in cells, causing slow wound healing and tissue regeneration; in this regard, a hydrogel dressing with antioxidant properties can promote wound healing; however, its design is still a challenge. Herein, a polydopamine/puerarin (PDA/PUE) nanoparticle-incorporated polyethylene glycol diacrylate hybrid hydrogel (PEG-DA/PDA/PUE) with antioxidant properties was prepared and used as a wound-healing material. Experimental observations indicated that the PEG-DA/PDA/PUE hydrogel possessed excellent swelling capacity and mechanical property. Moreover, the antioxidant capability was enhanced with an increase in the concentration of polydopamine/puerarin nanoparticles in the hydrogel. The hydrogel presented good cell proliferation and antioxidant activity, including a decrease in ROS and increase in the superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity under oxidative stress conditions. Furthermore, the full-thickness skin-defect-regeneration process could be accelerated via the antioxidant hydrogel treatment. This study validated the potential applications of an antioxidant hydrogel for wound healing.

Graphical abstract: Polydopamine/puerarin nanoparticle-incorporated hybrid hydrogels for enhanced wound healing

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Publication details

The article was received on 26 Jun 2019, accepted on 24 Jul 2019 and first published on 26 Jul 2019


Article type: Paper
DOI: 10.1039/C9BM00991D
Biomater. Sci., 2019, Advance Article

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    Polydopamine/puerarin nanoparticle-incorporated hybrid hydrogels for enhanced wound healing

    S. Zhang, Q. Ou, P. Xin, Q. Yuan, Y. Wang and J. Wu, Biomater. Sci., 2019, Advance Article , DOI: 10.1039/C9BM00991D

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