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Issue 47, 2019
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Magnetic carbon nanotubes grafted with smart polymer brushes for highly efficient enantioseparation of tryptophan enantiomers

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Abstract

We herein report a novel type of chiral carbon nanotube nanomaterial (MCNTs–PNG–CD) based on smart polymer brush grafted magnetic carbon nanotubes (MCNTs) for highly efficient chiral recognition and separation of tryptophan enantiomers (DL-Trp). The grafted PNG–CD smart polymer brushes are composed of thermosensitive poly(N-isopropyl acrylamide-co-glycidyl methacrylate) (PNG) copolymer chains with numerous appended beta-cyclodextrin (β-CD) units, which play a crucial role in efficient chiral discrimination and separation of DL-Trp. PNG–CD was fabricated on Fe3O4 nanoparticle-loaded carbon nanotubes (CNTs) by combining surface-initiated atom transfer radical polymerization (SI-ATRP) with a ring opening reaction. MCNTs–PNG–CD was systematically characterized by transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) and Raman spectroscopy, thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM) and elemental analysis (EA). The prepared MCNTs–PNG–CD demonstrates highly thermosensitive chiral recognition and enantioselectivity toward DL-Trp, which is based on host–guest interactions between β-CD units and L-tryptophan (L-Trp) and the thermosensitive volume phase transition of poly(N-isopropylacrylamide) (PNIPAM) chains. The operating temperature and initial concentrations of AAs are two significant factors that affect the chiral recognition and separation of DL-Trp. Furthermore, the obtained MCNTs–PNG–CD also exhibits satisfactory reusability and excellent magnetic separability from enantiomeric solutions. Such a multifunctional CNT nanomaterial can serve as a high-performance nanoselector for direct enantioseparation of various chiral compounds.

Graphical abstract: Magnetic carbon nanotubes grafted with smart polymer brushes for highly efficient enantioseparation of tryptophan enantiomers

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Publication details

The article was received on 14 Aug 2019, accepted on 10 Oct 2019 and first published on 11 Oct 2019


Article type: Paper
DOI: 10.1039/C9AY01736D
Anal. Methods, 2019,11, 5953-5962

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    Magnetic carbon nanotubes grafted with smart polymer brushes for highly efficient enantioseparation of tryptophan enantiomers

    X. Yang, L. Lei, Z. Peng, H. Yu and C. Cheng, Anal. Methods, 2019, 11, 5953
    DOI: 10.1039/C9AY01736D

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