Magnetic carbon nanotubes grafted with smart polymer brushes for highly efficient enantioseparation of tryptophan enantiomers
We herein report one novel type of chiral carbon nanotubes nanomaterials (MCNTs-PNG-CD) based on smart polymer brushes grafted magnetic carbon nanotubes (MCNTs) for highly efficient chiral recognition and separation of tryptophan enantiomers (DL-Trp). The grafted PNG-CD smart polymer brushes are composed of thermosensitive poly(N-isopropyl acrylamide-co-glycidyl methacrylate) (PNG) copolymer chains with numerous appended beta-cyclodextrin (β-CD) units, which play a crucial role in efficient chiral discrimination and separation of DL-Trp. The PNG-CD were fabricated on the Fe3O4 nanoparticles-loaded carbon nanotubes (CNTs) by combining surface-initiated atom transfer radical polymerization (SI-ATRP) with a ring opening reaction. The MCNTs-PNG-CD were systematically characterized by transmission electron microscope (TEM), Fourier transform infrared (FT-IR) and Roman spectroscopy, thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM) and elemental analysis (EA). The prepared MCNTs-PNG-CD demonstrate highly thermosensitive chiral recognition and enantioselectivity toward DL-Trp, which is based on host-guest interactions between β-CD units and L-tryptophan (L-Trp), and the thermosensitive volume phase transition of poly(N-isopropylacrylamide) (PNIPAM) chains. Operating temperature and initial concentrations of AAs are two significant factors that affect the chiral recognition and separation of DL-Trp. Furthermore, the obtained MCNTs-PNG-CD also exhibit satisfactory reusability and excellent magnetic separability from enantiomeric solutions. Such a multifunctional CNTs nanomaterial can serve as a high-performance nanoselector for direct enantioseparation of various chiral compounds.