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Issue 33, 2019
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An electrochemical aptasensor for detection of lead ions using a screen-printed carbon electrode modified with Au/polypyrrole composites and toluidine blue

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Abstract

An aptasensor based on the aptamer of lead(II) ions and the composites of Au nanoparticles and polypyrrole (Au@Py) was successfully fabricated. An Au@Py modified screen-printed electrode surface was employed to amplify the current signal. Complementary strands were successfully immobilized on the electrodes to combine with aptamers. The aptasensor with toluidine blue served as a redox indicator which was confirmed by electrochemical cyclic voltammetry methods as well as the differential pulse voltammetry technique in phosphate buffer solution (pH 7.4). Under optimal conditions, Pb2+ was detected in the range of 0.5–25 ppb with a low detection limit of 0.6 ppb (S/N = 3). Moreover, this electrochemical aptasensor was successfully applied to detect Pb2+ in soil. This electrochemical aptasensor exhibited satisfactory reproducibility, and is considered to possess great potential in developing an environmental monitoring platform.

Graphical abstract: An electrochemical aptasensor for detection of lead ions using a screen-printed carbon electrode modified with Au/polypyrrole composites and toluidine blue

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Publication details

The article was received on 15 Jun 2019, accepted on 25 Jul 2019 and first published on 31 Jul 2019


Article type: Paper
DOI: 10.1039/C9AY01256G
Anal. Methods, 2019,11, 4274-4279

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    An electrochemical aptasensor for detection of lead ions using a screen-printed carbon electrode modified with Au/polypyrrole composites and toluidine blue

    J. Ding, D. Zhang, Y. Liu, M. Yu, X. Zhan, D. Zhang and P. Zhou, Anal. Methods, 2019, 11, 4274
    DOI: 10.1039/C9AY01256G

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