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Issue 18, 2019
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Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

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Abstract

Primary anilines are essential building blocks to synthesize various pharmaceuticals, agrochemicals, pigments, electronic materials, and others. To date, the syntheses of primary anilines mostly rely on the reduction of nitroarenes or the transition-metal-catalyzed Ullmann, Buchwald–Hartwig and Chan–Lam cross-coupling reactions with ammonia, in which non-renewable petroleum-based chemicals are typically used as feedstocks via multiple step syntheses. A long-standing scientific challenge is to synthesize various primary anilines directly from renewable sources. Herein, we report a general method to directly convert a broad range of phenols into the corresponding primary anilines with the cheap and widely available hydrazine as both amine and hydride sources with simple Pd/C as the catalyst.

Graphical abstract: Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

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Publication details

The article was received on 02 Feb 2019, accepted on 26 Mar 2019 and first published on 26 Mar 2019


Article type: Edge Article
DOI: 10.1039/C9SC00595A
Chem. Sci., 2019,10, 4775-4781
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

    Z. Qiu, L. Lv, J. Li, C. Li and C. Li, Chem. Sci., 2019, 10, 4775
    DOI: 10.1039/C9SC00595A

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