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Ring-opening metathesis polymerization-induced self-assembly (ROMPISA) of a cisplatin analogue for high drug-loaded nanoparticles

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Abstract

We report the one-pot aqueous phase synthesis of cisplatin drug loaded micellar nanoparticles using Ring-Opening Metathesis Polymerization-Induced Self-Assembly (ROMPISA). ROMPISA was used to generate a small library of nanoparticles to examine the effect of size and charge on their action as cytotoxic agents against human ovarian and cervical cancer cells in vitro. The results show that polymerization-induced self-assembly (PISA) can easily yield drug loaded nanoparticles in one step at high solids concentrations in water for formulation of drugs at cytotoxic levels.

Graphical abstract: Ring-opening metathesis polymerization-induced self-assembly (ROMPISA) of a cisplatin analogue for high drug-loaded nanoparticles

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Publication details

The article was received on 29 Oct 2018, accepted on 25 Mar 2019 and first published on 25 Apr 2019


Article type: Communication
DOI: 10.1039/C8PY01539B
Polym. Chem., 2019, Advance Article

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    Ring-opening metathesis polymerization-induced self-assembly (ROMPISA) of a cisplatin analogue for high drug-loaded nanoparticles

    D. B. Wright, M. T. Proetto, M. A. Touve and N. C. Gianneschi, Polym. Chem., 2019, Advance Article , DOI: 10.1039/C8PY01539B

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