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Issue 28, 2019
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Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

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Abstract

Design, synthesis and functional analysis of fluorescent derivatives of neopeltolide, an antiproliferative marine macrolide, are reported herein. Live cell imaging using the fluorescent derivatives showed rapid cellular uptake and localization within the endoplasmic reticulum as well as the mitochondria.

Graphical abstract: Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

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Article information


Submitted
03 Jun 2019
Accepted
24 Jun 2019
First published
25 Jun 2019

Org. Biomol. Chem., 2019,17, 6771-6776
Article type
Communication

Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

S. Yanagi, T. Sugai, T. Noguchi, M. Kawakami, M. Sasaki, S. Niwa, A. Sugimoto and H. Fuwa, Org. Biomol. Chem., 2019, 17, 6771
DOI: 10.1039/C9OB01276A

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