Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 35, 2019
Previous Article Next Article

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

Author affiliations

Abstract

Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors.

Graphical abstract: A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

Back to tab navigation

Supplementary files

Article information


Submitted
15 May 2019
Accepted
12 Jun 2019
First published
05 Aug 2019

This article is Open Access

Org. Biomol. Chem., 2019,17, 8094-8105
Article type
Paper

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

W. Doherty, E. Dürr, H. T. Baddock, S. Y. Lee, P. J. McHugh, T. Brown, M. O. Senge, E. M. Scanlan and J. F. McGouran, Org. Biomol. Chem., 2019, 17, 8094
DOI: 10.1039/C9OB01133A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements