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Issue 19, 2019
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Pd(II)-Catalyzed C8–H alkoxycarbonylmethylation of 1-naphthylamides with α-chloroalkyl esters

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Abstract

An efficient protocol for palladium-catalyzed picolinamide directed C8–H alkoxycarbonylmethylation of 1-naphthylamine derivatives with α-chloroalkyl esters has been developed. The reaction exhibited a broad substrate scope and good functional group tolerance with high isolated yields. Note that α-chloroalkyl esters as a new type of alkylating reagent could be easily functionalized further due to their pending an ester group.

Graphical abstract: Pd(ii)-Catalyzed C8–H alkoxycarbonylmethylation of 1-naphthylamides with α-chloroalkyl esters

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Publication details

The article was received on 20 Mar 2019, accepted on 24 Apr 2019 and first published on 24 Apr 2019


Article type: Paper
DOI: 10.1039/C9OB00648F
Org. Biomol. Chem., 2019,17, 4865-4868

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    Pd(II)-Catalyzed C8–H alkoxycarbonylmethylation of 1-naphthylamides with α-chloroalkyl esters

    X. Wang, C. Feng, F. Yang and Y. Wu, Org. Biomol. Chem., 2019, 17, 4865
    DOI: 10.1039/C9OB00648F

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