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Issue 6, 2019
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The fate of cellulose nanocrystal stabilised emulsions after simulated gastrointestinal digestion and exposure to intestinal mucosa

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Abstract

It is well recognised that the average UK diet does not contain sufficient fibre. However, the introduction of fibre is often at the detriment of the organoleptic properties of a food. In this study on the gastrointestinal fate of nanoparticles, we have used cellulose nano-crystals (CNCs) as Pickering stabilising agents in oil in water emulsions. These emulsions were found to be highly stable against coalescence. The CNC and control emulsions were then exposed to simulated upper gastrointestinal tract digestion and the results compared to those obtained from a conventional protein stabilised emulsion. Finally the digested emulsions were exposed to murine intestinal mucosa and lipid and bile absorption was monitored. Importantly, the results show that the CNCs were entrapped in the intestinal mucus layer and failed to reach the underlying epithelium. This entrapment may also have led to the reduced absorption of saturated lipids from the CNC stabilised emulsion versus the control emulsion. The results show the potential of CNCs as a safe and effective emulsifier.

Graphical abstract: The fate of cellulose nanocrystal stabilised emulsions after simulated gastrointestinal digestion and exposure to intestinal mucosa

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Publication details

The article was received on 20 Jul 2018, accepted on 29 Oct 2018 and first published on 30 Jan 2019


Article type: Paper
DOI: 10.1039/C8NR05860A
Nanoscale, 2019,11, 2991-2998
  • Open access: Creative Commons BY license
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    The fate of cellulose nanocrystal stabilised emulsions after simulated gastrointestinal digestion and exposure to intestinal mucosa

    A. Mackie, S. Gourcy, N. Rigby, J. Moffat, I. Capron and B. Bajka, Nanoscale, 2019, 11, 2991
    DOI: 10.1039/C8NR05860A

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