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Issue 31, 2019
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Degradation of ZIF-8 in phosphate buffered saline media

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Abstract

Understanding the stability of zeolitic imidazolate framework-8 (ZIF-8) under physiological conditions is critical in biotechnology and biomedicine for biosensing, biocatalysis, and drug delivery. The use of ZIF-8 has shown that this metal organic framework (MOF) and its derived bio-composites can degrade in presence of buffer solutions. Here we present an in-depth analysis of the structural and chemical changes of pure ZIF-8 particles exposed to phosphate buffered saline (PBS) media. Two different particle sizes (2 μm and 250 nm) were selected and the decomposition operated by 10 mM PBS (aka 1X) was studied using powder X-ray diffraction (PXRD), Fourier transformed infrared spectroscopy (FTIR), time resolved atomic force microscopy (AFM), in situ small angle X-ray scattering (SAXS), and 31P NMR.

Graphical abstract: Degradation of ZIF-8 in phosphate buffered saline media

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Publication details

The article was received on 17 May 2019, accepted on 07 Jun 2019 and first published on 08 Jun 2019


Article type: Paper
DOI: 10.1039/C9CE00757A
CrystEngComm, 2019,21, 4538-4544
  • Open access: Creative Commons BY license
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    Degradation of ZIF-8 in phosphate buffered saline media

    M. D. J. Velásquez-Hernández, R. Ricco, F. Carraro, F. T. Limpoco, M. Linares-Moreau, E. Leitner, H. Wiltsche, J. Rattenberger, H. Schröttner, P. Frühwirt, E. M. Stadler, G. Gescheidt, H. Amenitsch, C. J. Doonan and P. Falcaro, CrystEngComm, 2019, 21, 4538
    DOI: 10.1039/C9CE00757A

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