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Issue 61, 2019
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Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

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Abstract

Cancer development is often associated with lipid metabolic reprogramming, including aberrant lipid accumulation. We create novel paradigms endowed with dual functions of anticancer activity and inhibition of lipid accumulation by conjugating the natural product quercetin and synthetic alkylphospholipid drugs, and harnessing the biomedical effects of both. These conjugates offer fresh perspectives in the search for anticancer candidates.

Graphical abstract: Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

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Publication details

The article was received on 27 May 2019, accepted on 14 Jun 2019 and first published on 04 Jul 2019


Article type: Communication
DOI: 10.1039/C9CC04084F
Chem. Commun., 2019,55, 8919-8922
  • Open access: Creative Commons BY license
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    Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

    Z. Zhou, B. Luo, X. Liu, M. Chen, W. Lan, J. L. Iovanna, L. Peng and Y. Xia, Chem. Commun., 2019, 55, 8919
    DOI: 10.1039/C9CC04084F

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