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Issue 61, 2019
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Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

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Abstract

Cancer development is often associated with lipid metabolic reprogramming, including aberrant lipid accumulation. We create novel paradigms endowed with dual functions of anticancer activity and inhibition of lipid accumulation by conjugating the natural product quercetin and synthetic alkylphospholipid drugs, and harnessing the biomedical effects of both. These conjugates offer fresh perspectives in the search for anticancer candidates.

Graphical abstract: Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

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Supplementary files

Article information


Submitted
27 May 2019
Accepted
14 Jun 2019
First published
04 Jul 2019

This article is Open Access

Chem. Commun., 2019,55, 8919-8922
Article type
Communication

Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

Z. Zhou, B. Luo, X. Liu, M. Chen, W. Lan, J. L. Iovanna, L. Peng and Y. Xia, Chem. Commun., 2019, 55, 8919
DOI: 10.1039/C9CC04084F

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