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Issue 51, 2019
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Aptamer-based regulation of transcription circuits

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Abstract

We propose synthetic DNA/RNA transcription circuits based on specific aptamer recognition. By mimicking transcription factor regulation, combined with specific enzyme/DNA aptamer binding, multiple biomolecules including DNA, RNA, polymerase, restriction enzymes and methylase were used as regulators. In addition, multi-level cascading networks and methylation-switch circuits were also established. This regulation strategy has the potential to expand the toolkit of in vitro synthetic biology.

Graphical abstract: Aptamer-based regulation of transcription circuits

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Publication details

The article was received on 23 Apr 2019, accepted on 30 May 2019 and first published on 31 May 2019


Article type: Communication
DOI: 10.1039/C9CC03141C
Chem. Commun., 2019,55, 7378-7381

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    Aptamer-based regulation of transcription circuits

    L. Pan, Y. Hu, T. Ding, C. Xie, Z. Wang, Z. Chen, J. Yang and C. Zhang, Chem. Commun., 2019, 55, 7378
    DOI: 10.1039/C9CC03141C

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